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Beings of ancient evil, known as Old Ones, are threatening to break out of their cosmic prison and awake into the world. Everything you know and love could be destroyed by chaos and madness. Can you and your fellow investigators manage to find and seal every portal in time? Hurry before you lose yourself to insanity.
Akado
Very similar to vanilla Pandemic, with a few Cthulhu-ish twists. The flaws in the game are too similar to base Pandemic for my tastes, though (complete reliance on shuffle, little or no ways to influence that).
andrewrothfuss
A bit of a contradiction. It wants to be all serious and weighty with the Cthulhu theming and madness mechanics, but it's actually the quickest and lightest version of the traditional Pandemic games. Not that it's a bad, it's just unexpected. In fact that lightness actually sets it apart from all the other versions.
almond_jester
Solid. Perhaps a bit too well-trimmed of a Cthulhu mythos game when compared to the mayhem that is Arkham Horror.